I am the 高级主管 and Head of Cell Therapy Bioprocess 发展 and Manufacturing, 澳门葡京赌博游戏的细胞治疗部门&澳门葡京网赌游戏的博士. 在这个角色中, I am responsible for leading on the translational technology and development of high-quality cells for pre-clinical research, to enable the efficient research and development of cell-based therapeutics.

I bring more than 20 years of experience ranging from applied research through to manufacturing and regulatory compliance of stem cell-derived products. 我在干细胞生物技术方面的专长, standardisation and advanced therapies regulation areas has enabled my participation in several national and international committees where I have supported regulatory compliance and delivery of advanced therapy medicinal products.

我有化学工程学位，并获得了博士学位.D in Stem Cell 生物技术 from the Technical University of Lisbon. 从那时起, 我已经完成了多个合作项目, both in academia and within the UK Regulator (药物 and Healthcare products Regulatory Agency), which assured the quality of clinical grade stem cell lines alongside a programme of cell and gene therapy standardisation.

The cell therapy department at AstraZeneca is a centralised hub of highly skilled people working together across disease areas to improve the lives of patients around the world. Each day I am excited to be a part of a team that maximises collaboration to show what science can do.

埃尔莎Abranches 高级主管, Head of Cell Therapy Bioprocess 发展 and Manufacturing, 澳门葡京赌博游戏R&D
艾莎·布兰奇的大头照, 高级主管, Head of Cell Therapy Bioprocess 发展 and Manufacturing, 澳门葡京赌博游戏R&澳门葡京网赌游戏的博士

电流的作用

高级主管, Head of Cell Therapy Bioprocess 发展 and Manufacturing, 澳门葡京赌博游戏R&D、澳门葡京网赌游戏

为世卫组织起草细胞和基因治疗指南

Contributed to the WHO approach towards the development of a global regulatory framework for cell and gene therapy products

2020年:赚了1英镑.2 m格兰特

Successfully secured grant funding from the National Institute for Health and Care 研究 (NIHR) to support the maintenance of the UK public repository of human embryonic stem cell lines

2019年:获得世卫组织认可

Endorsed for the development of the first ATMP flow cytometry reference reagent

2017年:赚2英镑.1米格兰特

Successfully secured grant funding from the Medical 研究 Council to bank clinical grade stem cell lines

科学出版物

英国干细胞库

O'Shea O, branches E. 干细胞研究 (2020), 49, 102019.

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GMP Banking of Human Pluripotent Stem Cells: A US and UK perspective

布兰斯E，斯派鲁S，路德维希T. 干细胞研究 (2020), 45, 101805.

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Distributed automated manufacturing of pluripotent stem cell products

Shariatzadeh米, 钱德拉一, 威尔逊SL, 考尔乔丹, Morizur L, Lesueur L, 选择阿, Gepp毫米, 舒尔茨一, 纽鲍尔JC, 齐默尔曼H, Abranches E, 等. 国际广告制造技术公司 (2020), 106 (3), 1085-1103.

 

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Neuromesodermal progenitors and the making of the spinal cord

Henrique D, abraches E, Verrier L, Storey KG. 发展 (2015), 142 (17), 2864-75.

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Heterogeneous lineage marker expression in naive embryonic stem cells is mostly due to spontaneous differentiation

Nair G, abches E, Guedes AM, Henrique D, Raj A. 科学报告 (2015), 5, 13339.

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Imaging pluripotency: time-lapse analysis of mouse embryonic stem cells

pezzarrossa A, Guedes AM, Henrique D, Abranches E. 胚胎干细胞方案 - 3nd Edition, Series: Methods in Molecular Biology (Clifton, NJ), Springer Protocols (2015).

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Stochastic Nanog fluctuations allow mouse embryonic stem cells to explore pluripotency

Abranches E.格德斯，A. M.莫拉维克，M.，先生，H.，斯沃博达，P.拉杰，A.亨利克，D. 发展 (2014), 141 (14), 2770-2779.

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Glycogen synthase kinase-3 inhibition enhances translation of pluripotency-associated transcription factors to contribute to maintenance of mouse embryonic stem cell self-renewal

Sanchez-Ripoll Y, Bone HK, Owen T, Guedes AM., Abranches E, Kumpfmueller B, Spriggs RV, Henrique D, Welham, MJ, 等. 《澳门葡京网赌游戏》 (2013), 8 (4), e60148.

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Generation and characterization of a novel embryonic stem cell line with a dynamic reporter of NANOG expression

Abranches E.贝克曼，E., & 恩里克,D. 《澳门葡京网赌游戏》 (2013), 8 (3), e59928.

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随机单基因自动调节

阿基诺T，布兰奇斯E，努内斯A. 物理Rev E Stat非线性软物质物理 (2012), 85 (6-1), 061913.

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Neural Differentiation of Embryonic Stem Cells in vitro: A Road Map to Neurogenesis in the Embryo

Abranches E, Silva M, Pradier L, Schulz H, Hummel O, Henrique D, Bekman E. 《澳门葡京网赌游戏》 (2009), 4 (7), e6286.

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Bilirubin as a determinant for altered neurogenesis, neuritogenesis, and synaptogenesis

Fernandes A, Falcão AS, Abranches E, Bekman E, Henrique D, Lanier L, Brites D. 发育神经生物学 (2009), 69 (9), 568-582

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小鼠胚胎干细胞在微载体上的扩增

刘国强，刘国强，刘国强. 生物技术 & 生物工程 (2007), 96 (6), 1211-1221.

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发展 of quantitative PCR protocols to analyze neural progenitor cell culture state

Abranches E, O'Neill A, Robertson MJ, Schaffer DV, Cabral JM. 生物技术与应用生物化学 (2006), 44 (Pt 1), 1-8.

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Expansion and neural differentiation of embryonic stem cells in adherent and suspension cultures

刘国强，刘国强，刘国强. 生物技术信 (2003), 25, 725-730.

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Veeva ID: Z4-52092
编制日期:2023年1月